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Workshop Program

More information to come

Sept 4, 2024

Workshop Day 1 

- Welcome & Opening of Workshop

8:45am-9:45am 

Session Chairs: Mohit Kapoor, Sarah Rice & Yolande Ramos

8:45am-9:30am 

Registration & Coffee

9:30am-9:45am

Welcome & Opening of Workshop

9:45am-11:20am 

- Session 1: Omic Technologies & Application to Osteoarthritis

Session Chairs: TBD

9:45 am-10:10am

Keynote Speaker: Terence Capellini

Talk Title: The Regulation of Human Skeletal Development & its Impacts on Osteoarthritis Risk 

10:10am-10:20am

Hayley Peters

Abstract Title: Cell and transcriptomic diversity of infrapatellar fat pad during knee osteoarthritis 

10:20am-10:30am

Arin Oestreich

Abstract Title: Multiomic single nucleus sequencing reveals metabolic dysregulation and epigenetic changes in fetal chondrocytes exposed to the obese uterine environment

10:30am-10:40am

Rick Mulders

Abstract Title: Mapping of Chondrogenic Differentiation of Human Induced Pluripotent Stem Cells by Single-Cell Multi-Omics

10:40am-11:00am

Talk Title: Response eQTLs, chromatin accessibility, and 3D chromatin structure in chondrocytes provide mechanistic insight into osteoarthritis risk

11:00am-11:20am

Speaker Panel Discussion

11:20am-12:30pm

- Lunch and Networking

12:30pm-2:20pm

- Session 2: Epigenetic Mechanisms of Osteoarthritis

Session Chairs: TBD

12:30pm-12:50pm

Talk Title: Epigenetics in Knee Osteoarthritis: Disentangling Pain from OA Processes

12:50pm-1:00pm

Astrid de Roover

Abstract Title: Peroxisomal Transporter ABCD3 promotes H3K79 Methylation and maintains a Healthy Chondrocyte Molecular Identity

1:00pm-1:10pm

Clarissa Coveney

Abstract Title: Interaction of regulatory elements at the GDF5 locus act to drive, restrict or repress expression, impacting joint morphology, and disease risk

1:10pm-1:20pm

Sarah Orr 

Abstract Title: Mapping the epigenetic risk of osteoarthritis in hip development and disease

1:20pm-1:30pm

Ye Liu

Abstract Title: H3K9me3 loss and ERV activation as hallmarks for  osteoarthritis progression and knee joint aging 

1:30pm-1:40pm

Thomas Wilson

Abstract Title: Characterizing novel microRNAs in early-stage radiographic knee osteoarthritis

1:40pm-2:00pm

Speaker: Jeroen Geurts

Talk Title: Epigenetic Regulation of subchondral bone and marrow adipose tissues in OA

2:00pm-2:20pm

Speaker Panel Discussion

2:20pm-2:45pm

- Coffee Break

2:45pm-3:30pm

- Session 3: Data Analytics & Machine Learning

Session Chairs: TBD

2:45pm-3:05pm

Speaker: Igor Jurisica

Talk Title: Harnessing Real & Artificial Intelligence for Multi-Omic Data Analysis in OA

3:05pm-3:15pm

Noah Fine

Abstract Title: Candidate Epigenetic Polygenic Risk Score (E-PRS) to Predict Pain Response Following Surgical Intervention for Lumbar Spinal Stenosis due to Spine Osteoarthritis

3:15pm-3:25pm

Myriam Brossard

Abstract Title: A new colocalization analysis method to characterize shared genetic association between microRNA and osteoarthritis outcomes 

3:25pm-3:30pm

Speaker Panel Discussion

- Break

3:30pm-3:45pm

3:45pm-4:25pm

- Session 4: Scientific Integrity Discussion & Abstract Pitches

Session Chairs: TBD

3:45pm-4:00pm

Speaker: Cindy Boer

Talk Title: Tilting against papermills: Fraudulent Research in Osteoarthritis

4:00pm-4:10pm

Discussion

4:10pm-4:25pm

Selected Abstract Pitches

Narman Mortagy

Pitch Title: MicroRNA profiles in synovial fluid as indicators of equine joint health

Kabriya Thavaratnam

Pitch Title: An atlas of the synovium in knee osteoarthritis: fibroblast activation defines disease progression

Amit Sandhu 

Pitch Title: Early MicroRNA and Metabolite Changes Post-ACL Reconstruction: Molecular Insights

Madhu Baghel

Pitch Title: Sequencing Identifies Unique Circulating MicroRNAs in Early Osteoarthritis and Early Rheumatoid Arthritis  

End of Day 1

6:00pm-9:00pm

- Workshop Cocktail and Dinner

6:00pm-7:00pm

Meet and Greet (Cocktail)

7:00pm-9:00pm

Workshop Dinner

Workshop Day 2 

Sept 5, 2024

8:30am-9:00am

- Breakfast and Networking Session

9:00am-10:10am

- Session 5: Epigenetics as Biomarkers for Osteoarthritis

Session Chairs: TBD

9:00am-9:05am

Welcome and Introduction

9:05am-9:25am

Speaker: Amanda Ali

Talk Title: Rethinking microRNA-sequencing for biomarker discovery

9:25am-9:35am

Jason Rockel

Abstract Title: Deep learning-based multimodal clustering for endotyping and longitudinal response prediction using knee osteoarthritis patient-matched multi-omic data 

9:35am-9:45am

Matlock Jeffries

Abstract Title: Preclinical OA can be defined by baseline peripheral blood DNA methylation models which predict the development of radiographic OA up to 8 years in advance

9:45am-9:55am

Maria de Andres

Abstract Title: Both circulating levels of miR-140-5p and Mediterranean diet adherence as significant contributors of a clinical model to predict the risk of incidence knee osteoarthritis: data from the Osteoarthritis Initiative

9:55am-10:10am

Speaker Panel Discussion

10:10am-11:45am

- Coffee Break

10:45am-12:10pm

- Session 6: Pharmacological Targeting of the OA Epigenome

Session Chairs: TBD

10:45-11:05am

Speaker: Rik Lories

Talk Title: Histone modification in cartilage health and disease - a DOT1L story 

11:05am-11:15am

Carmen Nunez Carro 

Abstract Title: Dietary intake of extra virgin olive oil acts at epigenetic level to attenuate the progression of experimental osteoarthritis in mice

11:15am-11:25am

Asmaa El Maarbani 

Abstract Title: Effects of a Ketogenic Diet on the Progression of Osteoarthritis in Obese Mice - Articular, Metabolic and Epigenetic Characterization

11:25am-11:35am

T Connor McCorkell 

Abstract Title: Assessment of Safety of Intraarticular Injection of microRNA-181a-5p Antisense Oligonucleotides in Clinically Normal Equine Fetlock Joints

11:35am-11:55am

Speaker: Tom Appleton

Talk Title: Synovitis, pain, and single cell signalling networks in OA

11:55am-12:10pm

Speaker Panel Discussion

12:10pm-1:15pm

- Lunch and Networking

1:15pm-2:45pm

- Session 7: Epigenome Modulation & Osteoarthritis

Session Chairs: TBD

1:15pm-1:35pm

Speaker: Nidhi Bhutani

Talk Title: Modulating the OA Epigenome

11:35am-11:45am

Jack Roberts

Abstract Title: Specific isoforms of the ubiquitin ligase gene WWP2 are targets of osteoarthritis genetic risk via a differentially methylated DNA sequence

11:45am-11:55am

Seyoun Byun

Abstract Title: Splicing response QTLs identify putative osteoarthritis risk genes

1:55pm-2:20pm

Keynote Speaker: Laura Stone

Talk Title: DNA Methylation and Low Back Pain: Past, Present and Future

2:20pm-2:35pm

Speaker Panel Discussion 

2:35pm-2:45pm

Recap and Prizes

2:45pm-3:00pm

- Closing Remarks

End of Workshop
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