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Workshop Program
More information to come
Sept 4, 2024
Workshop Day 1
- Welcome & Opening of Workshop
8:45am-9:45am
Session Chairs: Mohit Kapoor, Sarah Rice & Yolande Ramos
8:45am-9:30am
Registration & Coffee
9:30am-9:45am
Welcome & Opening of Workshop
9:45am-11:20am
- Session 1: Omic Technologies & Application to Osteoarthritis
Session Chairs: Rick Mulders and Anca Maglaviceanu
9:45 am-10:10am
Keynote Speaker: Terence Capellini
Talk Title: The Regulation of Human Skeletal Development & its Impacts on Osteoarthritis Risk
10:10am-10:20am
Hayley Peters
Abstract Title: Cell and transcriptomic diversity of infrapatellar fat pad during knee osteoarthritis
10:20am-10:30am
Arin Oestreich
Abstract Title: Multiomic single nucleus sequencing reveals metabolic dysregulation and epigenetic changes in fetal chondrocytes exposed to the obese uterine environment
10:30am-10:40am
Rick Mulders
Abstract Title: Mapping of Chondrogenic Differentiation of Human Induced Pluripotent Stem Cells by Single-Cell Multi-Omics
10:40am-11:00am
Invited Speaker: Douglas Phanstiel
Talk Title: Response eQTLs, chromatin accessibility, and 3D chromatin structure in chondrocytes provide mechanistic insight into osteoarthritis risk
11:00am-11:20am
Speaker Panel Discussion
11:20am-12:30pm
- Lunch and Networking
12:30pm-2:20pm
- Session 2: Epigenetic Mechanisms of Osteoarthritis
Session Chairs: Jack Roberts and Atoosa Ziyaeyan
12:30pm-12:50pm
Invited Speaker: Yenisel Cruz-Almeida
Talk Title: Epigenetics in Knee Osteoarthritis: Disentangling Pain from OA Processes
12:50pm-1:00pm
Astrid de Roover
Abstract Title: Peroxisomal Transporter ABCD3 promotes H3K79 Methylation and maintains a Healthy Chondrocyte Molecular Identity
1:00pm-1:10pm
Clarissa Coveney
Abstract Title: Interaction of regulatory elements at the GDF5 locus act to drive, restrict or repress expression, impacting joint morphology, and disease risk
1:10pm-1:20pm
Sarah Orr
Abstract Title: Mapping the epigenetic risk of osteoarthritis in hip development and disease
1:20pm-1:30pm
Tao Yang
Abstract Title: H3K9me3 loss and ERV activation as hallmarks for osteoarthritis progression and knee joint aging
1:30pm-1:40pm
Thomas Wilson
Abstract Title: Characterizing novel microRNAs in early-stage radiographic knee osteoarthritis
1:40pm-2:00pm
Invited Speaker: Jeroen Geurts
Talk Title: Epigenetic Regulation of subchondral bone and marrow adipose tissues in OA
2:00pm-2:20pm
Speaker Panel Discussion
2:20pm-2:45pm
- Coffee Break
2:45pm-3:30pm
- Session 3: Data Analytics & Machine Learning
Session Chairs: Mozhgan Rasti and Jason Rockel
2:45pm-3:05pm
Invited Speaker: Igor Jurisica
Talk Title: Harnessing Real & Artificial Intelligence for Multi-Omic Data Analysis in OA
3:05pm-3:15pm
Noah Fine
Abstract Title: Candidate Epigenetic Polygenic Risk Score (E-PRS) to Predict Pain Response Following Surgical Intervention for Lumbar Spinal Stenosis due to Spine Osteoarthritis
3:15pm-3:25pm
Myriam Brossard
Abstract Title: A new colocalization analysis method to characterize shared genetic association between microRNA and osteoarthritis outcomes
3:25pm-3:30pm
Speaker Panel Discussion
- Break
3:30pm-3:45pm
3:45pm-4:25pm
- Session 4: Scientific Integrity Discussion & Abstract Pitches
Session Chairs: Arin Oestreich and Matlock Jeffries
3:45pm-4:00pm
Invited Speaker: Cindy Boer
Talk Title: Tilting against papermills: Fraudulent Research in Osteoarthritis
4:00pm-4:10pm
Discussion
4:10pm-4:25pm
Selected Abstract Pitches
Narman Mortagy
Pitch Title: MicroRNA profiles in synovial fluid as indicators of equine joint health
Kabriya Thavaratnam
Pitch Title: An atlas of the synovium in knee osteoarthritis: fibroblast activation defines disease progression
Amit Sandhu
Pitch Title: Early MicroRNA and Metabolite Changes Post-ACL Reconstruction: Molecular Insights
Thomas Wilson
Pitch Title: Sequencing Identifies Unique Circulating MicroRNAs in Early Osteoarthritis and Early Rheumatoid Arthritis
End of Day 1
6:00pm-9:00pm
- Workshop Cocktail and Dinner
6:00pm-7:00pm
Meet and Greet (Cocktail)
7:00pm-9:00pm
Workshop Dinner
Workshop Day 2
Sept 5, 2024
8:30am-9:00am
- Breakfast and Networking Session
9:00am-10:10am
- Session 5: Epigenetics as Biomarkers for Osteoarthritis
Session Chairs: Carmen Nunez Carro and Thomas Wilson
9:00am-9:05am
Welcome and Introduction
9:05am-9:25am
Invited Speaker: Amanda Ali
Talk Title: Rethinking microRNA-sequencing for biomarker discovery
9:25am-9:35am
Jason Rockel
Abstract Title: Deep learning-based multimodal clustering for endotyping and longitudinal response prediction using knee osteoarthritis patient-matched multi-omic data
9:35am-9:45am
Matlock Jeffries
Abstract Title: Preclinical OA can be defined by baseline peripheral blood DNA methylation models which predict the development of radiographic OA up to 8 years in advance
9:45am-9:55am
Maria de Andres
Abstract Title: Both circulating levels of miR-140-5p and Mediterranean diet adherence as significant contributors of a clinical model to predict the risk of incidence knee osteoarthritis: data from the Osteoarthritis Initiative
9:55am-10:10am
Speaker Panel Discussion
10:10am-10:45am
- Coffee Break
10:45am-12:10pm
- Session 6: Pharmacological Targeting of the OA Epigenome
Session Chairs: Astrid de Roover and Noah Fine
10:45-11:05am
Invited Speaker: Rik Lories
Talk Title: Histone modification in cartilage health and disease - a DOT1L story
11:05am-11:15am
Carmen Nunez Carro
Abstract Title: Dietary intake of extra virgin olive oil acts at epigenetic level to attenuate the progression of experimental osteoarthritis in mice
11:15am-11:25am
Asmaa El Maarbani
Abstract Title: Effects of a Ketogenic Diet on the Progression of Osteoarthritis in Obese Mice - Articular, Metabolic and Epigenetic Characterization
11:25am-11:35am
T Connor McCorkell
Abstract Title: Assessment of Safety of Intraarticular Injection of microRNA-181a-5p Antisense Oligonucleotides in Clinically Normal Equine Fetlock Joints
11:35am-11:55am
Invited Speaker: Tom Appleton
Talk Title: Synovitis, pain, and single cell signalling networks in OA
11:55am-12:10pm
Speaker Panel Discussion
12:10pm-1:15pm
- Lunch and Networking
1:15pm-2:45pm
- Session 7: Epigenome Modulation & Osteoarthritis
Session Chairs: Asmaa El Maarbani and Emma Klein
1:15pm-1:35pm
Invited Speaker: Nidhi Bhutani
Talk Title: Modulating the OA Epigenome
1:35pm-1:45pm
Jack Roberts
Abstract Title: Specific isoforms of the ubiquitin ligase gene WWP2 are targets of osteoarthritis genetic risk via a differentially methylated DNA sequence
1:45pm-1:55pm
Seyoun Byun
Abstract Title: Splicing response QTLs identify putative osteoarthritis risk genes
1:55pm-2:20pm
Keynote Speaker: Laura Stone
Talk Title: DNA Methylation and Low Back Pain: Past, Present and Future
2:20pm-2:35pm
Speaker Panel Discussion
2:35pm-2:45pm
Recap and Prizes
2:45pm-3:00pm
- Closing Remarks
End of Workshop
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